| 9/4/2010 | Virginia Union Panthers 27 @ Shaw 57 | † |
| 9/11/2010 | Shaw 26 @ Elon Phoenix 55 | |
| 9/18/2010 | Shaw 21 @ Catawba Indians 32 | |
| 9/25/2010 | Shaw 31 @ Elizabeth City State Vikings 28 | † |
| 10/2/2010 | Shaw 34 @ Livingstone Blue Bears 0 | † |
| 10/9/2010 | Shaw 45 @ Johnson C Smith Golden Bulls 13 | † |
| 10/16/2010 | Fayetteville State Broncos 27 @ Shaw 34 | † |
| 10/23/2010 | Chowan Braves 14 @ Shaw 35 | † |
| 10/30/2010 | Winston-Salem State Rams 27 @ Shaw 31 | † |
| 11/6/2010 | Shaw 10 @ St Augustine's Falcons 6 | † |
| 11/13/2010 | Shaw 14 vs Virginia State Trojans 7 (Durham NC) | † |
| 11/20/2010 | Shaw 6 @ Shepherd Rams 40 |