| 9/18/2010 | Holy Cross Crusaders 6 @ Harvard 34 | |
| 9/25/2010 | Harvard 14 @ Brown Bears 29 | † |
| 10/2/2010 | Harvard 35 @ Lafayette Leopards 10 | |
| 10/9/2010 | Cornell Rams 17 @ Harvard 31 | † |
| 10/16/2010 | Lehigh Mountain Hawks 21 @ Harvard 19 | |
| 10/23/2010 | Harvard 45 @ Princeton Tigers 28 | † |
| 10/30/2010 | Harvard 30 @ Dartmouth Corsairs 14 | † |
| 11/6/2010 | Columbia Lions 7 @ Harvard 23 | † |
| 11/13/2010 | Harvard 14 @ Pennsylvania Quakers 34 | † |
| 11/20/2010 | Yale Bulldogs 21 @ Harvard 28 | † |