| 9/18/2010 | Fordham Rams 16 @ Columbia 9 | |
| 9/25/2010 | Towson Tigers 10 @ Columbia 24 | |
| 10/2/2010 | Princeton Tigers 14 @ Columbia 42 | † |
| 10/9/2010 | Lafayette Leopards 28 @ Columbia 42 | |
| 10/16/2010 | Columbia 13 @ Pennsylvania Quakers 27 | † |
| 10/23/2010 | Dartmouth Corsairs 24 @ Columbia 21 | † |
| 10/30/2010 | Columbia 28 @ Yale Bulldogs 31 | † |
| 11/6/2010 | Columbia 7 @ Harvard Crimson 23 | † |
| 11/13/2010 | Cornell Rams 17 @ Columbia 20 | † |
| 11/20/2010 | Columbia 16 @ Brown Bears 38 | † |