| 9/4/2010 | Western Carolina | @ | North Carolina St | ||||||
| 9/11/2010 | Tusculum D2 | @ | Western Carolina | ||||||
| 9/18/2010 | Western Carolina | @ | Gardner Webb | ||||||
| 9/25/2010 | Chattanooga | @ | Western Carolina | SoCon | |||||
| 10/2/2010 | Western Carolina | @ | The Citadel | SoCon | |||||
| 10/9/2010 | Samford | @ | Western Carolina | SoCon | |||||
| 10/16/2010 | Western Carolina | @ | Wofford | SoCon | |||||
| 10/23/2010 | Appalachian St | @ | Western Carolina | SoCon | |||||
| 11/6/2010 | Western Carolina | @ | Furman | SoCon | |||||
| 11/13/2010 | Ga Southern | @ | Western Carolina | SoCon | |||||
| 11/20/2010 | Western Carolina | @ | Elon | SoCon |