| 9/4/2010 | Samford | @ | Florida St | ||||||
| 9/11/2010 | Samford | @ | Northwestern St | ||||||
| 9/16/2010 | Newberry D2 | @ | Samford | ||||||
| 9/25/2010 | Appalachian St | @ | Samford | SoCon | |||||
| 10/2/2010 | Samford | @ | Elon | SoCon | |||||
| 10/9/2010 | Samford | @ | Western Carolina | SoCon | |||||
| 10/16/2010 | Furman | @ | Samford | SoCon | |||||
| 10/30/2010 | Samford | @ | Ga Southern | SoCon | |||||
| 11/6/2010 | Wofford | @ | Samford | SoCon | |||||
| 11/13/2010 | Samford | @ | Chattanooga | SoCon | |||||
| 11/20/2010 | The Citadel | @ | Samford | SoCon |