| 9/11/2010 | Georgetown | @ | Lafayette | Pat | |||||
| 9/18/2010 | Lafayette | @ | Penn | ||||||
| 9/25/2010 | Lafayette | @ | Princeton | ||||||
| 10/2/2010 | Harvard | @ | Lafayette | ||||||
| 10/9/2010 | Lafayette | @ | Columbia | ||||||
| 10/16/2010 | Stony Brook | @ | Lafayette | ||||||
| 10/23/2010 | Lafayette | @ | Fordham | Pat | |||||
| 10/30/2010 | Lafayette | @ | Bucknell | Pat | |||||
| 11/6/2010 | Lafayette | @ | Colgate | Pat | |||||
| 11/13/2010 | Holy Cross | @ | Lafayette | Pat | |||||
| 11/20/2010 | Lehigh | @ | Lafayette | Pat |