11 Jan 2011 5:05pm (US Central)
| 0-1 | — | 0 | (1 Common Ops) | 0 | Akron | 1-11 |
| L 0-31 at | 9/2/2010 | Buffalo (1-9) | 11/26/2010 | W 22-14 |
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| 0-1 | — | 0 | (1 Common Ops) | 0 | Ball State | 4-8 |
| L 0-31 at | 9/2/2010 | Buffalo (1-9) | 11/12/2010 | W 20-3 at |
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| 0-1 | — | 0 | (1 Common Ops) | 0 | Baylor | 7-6 |
| L 0-31 at | 9/2/2010 | Buffalo (1-9) | 9/11/2010 | W 34-6 |
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| 0-1 | — | 0 | (1 Common Ops) | 0 | Bowling Green | 2-10 |
| L 0-31 at | 9/2/2010 | Buffalo (0-10) | 10/2/2010 | L 26-28 |
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| 0-1 | — | 0 | (1 Common Ops) | 0 | Connecticut | 8-5 |
| L 0-31 at | 9/2/2010 | Buffalo (1-9) | 9/25/2010 | W 45-21 |
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| 0-1 | — | 0 | (1 Common Ops) | 0 | Eastern Michigan | 2-10 |
| L 0-31 at | 9/2/2010 | Buffalo (1-9) | 11/20/2010 | W 21-17 at |
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| 0-1 | — | 0 | (1 Common Ops) | 0 | Miami-Ohio | 10-4 |
| L 0-31 at | 9/2/2010 | Buffalo (1-9) | 10/30/2010 | W 21-9 at |
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| 0-1 | — | 0 | (1 Common Ops) | 0 | Northern Illinois | 11-3 |
| L 0-31 at | 9/2/2010 | Buffalo (1-9) | 10/16/2010 | W 45-14 |
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| 0-1 | — | 0 | (1 Common Ops) | 0 | Ohio | 8-5 |
| L 0-31 at | 9/2/2010 | Buffalo (1-9) | 11/4/2010 | W 34-17 |
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| 0-1 | — | 0 | (1 Common Ops) | 0 | Temple | 8-4 |
| L 0-31 at | 9/2/2010 | Buffalo (1-9) | 10/23/2010 | W 42-0 at |
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| 0-1 | — | 0 | (1 Common Ops) | 0 | UCF | 11-3 |
| L 0-31 at | 9/2/2010 | Buffalo (1-9) | 9/18/2010 | W 24-10 at |
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