| 9/10/2005 | Florida Intl | 3 | @ | #15 Texas Tech | 56 | ||||
| 9/17/2005 | Sam Houston | 21 | @ | #15 Texas Tech | 80 | ||||
| 9/24/2005 | Indiana St | 7 | @ | #15 Texas Tech | 63 | ||||
| 10/1/2005 | Kansas | 17 | @ | #15 Texas Tech | 30 | B12 | |||
| 10/8/2005 | #15 Texas Tech | 34 | @ | Nebraska | 31 | B12 | |||
| 10/15/2005 | Kansas St | 20 | @ | #15 Texas Tech | 59 | B12 | |||
| 10/22/2005 | #15 Texas Tech | 17 | @ | #2 Texas | 52 | B12 | |||
| 10/29/2005 | #15 Texas Tech | 28 | @ | Baylor | 0 | B12 | |||
| 11/5/2005 | Texas A&M | 17 | @ | #15 Texas Tech | 56 | B12 | |||
| 11/12/2005 | #15 Texas Tech | 17 | @ | Oklahoma St | 24 | B12 | |||
| 11/19/2005 | Oklahoma | 21 | @ | #15 Texas Tech | 23 | B12 | |||
| 1/2/2006 | #13 Alabama | 13 | vs | #15 Texas Tech | 10 | Cotton |