| 9/3/2005 | #14 TCU | 17 | @ | Oklahoma | 10 | ||||
| 9/10/2005 | Tulsa | 15 | @ | Oklahoma | 31 | ||||
| 9/17/2005 | Oklahoma | 24 | @ | #17 UCLA | 41 | ||||
| 10/1/2005 | Kansas St | 21 | @ | Oklahoma | 43 | B12 | |||
| 10/8/2005 | Oklahoma | 12 | vs | #2 Texas | 45 | B12 | Dallas TX | ||
| 10/15/2005 | Oklahoma | 19 | vs | Kansas | 3 | B12 | Kansas City MO | ||
| 10/22/2005 | Baylor | 30 | @ | Oklahoma | 37 | 2 OT | B12 | ||
| 10/29/2005 | Oklahoma | 31 | @ | Nebraska | 24 | B12 | |||
| 11/12/2005 | Texas A&M | 30 | @ | Oklahoma | 36 | B12 | |||
| 11/19/2005 | Oklahoma | 21 | @ | #15 Texas Tech | 23 | B12 | |||
| 11/26/2005 | Oklahoma St | 14 | @ | Oklahoma | 42 | B12 | |||
| 12/29/2005 | Oklahoma | 17 | vs | #5 Oregon | 14 | Holiday |