| 9/1/2005 | Buffalo | 0 | @ | Connecticut | 38 | ||||
| 9/10/2005 | Buffalo | 0 | @ | Syracuse | 31 | ||||
| 9/17/2005 | Rutgers | 17 | @ | Buffalo | 3 | ||||
| 10/1/2005 | Buffalo | 21 | @ | Western Michigan | 31 | MAC | |||
| 10/8/2005 | Akron | 13 | @ | Buffalo | 7 | MAC | |||
| 10/15/2005 | Bowling Green | 27 | @ | Buffalo | 7 | MAC | |||
| 10/22/2005 | Buffalo | 15 | @ | Toledo | 38 | MAC | |||
| 10/29/2005 | Ohio | 34 | @ | Buffalo | 20 | MAC | |||
| 11/5/2005 | Buffalo | 13 | @ | Miami-Ohio | 54 | MAC | |||
| 11/12/2005 | Buffalo | 10 | @ | Kent St | 6 | MAC | |||
| 11/19/2005 | Eastern Michigan | 38 | @ | Buffalo | 14 | MAC |