| 9/1/2005 | Western Illinois | 14 | @ | Toledo | 62 | ||||
| 9/10/2005 | Western Michigan | 23 | @ | Toledo | 56 | MAC | |||
| 9/17/2005 | Toledo | 42 | @ | Temple | 17 | ||||
| 9/27/2005 | Toledo | 14 | @ | Fresno St | 44 | ||||
| 10/8/2005 | Eastern Michigan | 3 | @ | Toledo | 30 | MAC | |||
| 10/15/2005 | Toledo | 34 | @ | Ball State | 14 | MAC | |||
| 10/22/2005 | Buffalo | 15 | @ | Toledo | 38 | MAC | |||
| 10/29/2005 | Toledo | 17 | @ | Central Michigan | 21 | MAC | |||
| 11/4/2005 | Toledo | 30 | @ | Ohio | 21 | MAC | |||
| 11/16/2005 | Northern Illinois | 35 | @ | Toledo | 17 | MAC | |||
| 11/22/2005 | Toledo | 44 | @ | Bowling Green | 41 | MAC | |||
| 12/21/2005 | UTEP | 13 | vs | Toledo | 45 | GMAC |