| 8/31/2024 | Austin Peay (4-8) | 0 | at | Louisville | 62 | UAC (1AA) | ||
| 9/7/2024 | Jacksonville State (9-5) | 14 | at | Louisville | 49 | CUSA | ||
| 9/21/2024 | Georgia Tech (7-6,5-3) | 19 | at | Louisville | 31 | |||
| 9/28/2024 | Louisville | 24 | at | Notre Dame (14-2) | 31 | at ND | ||
| 10/5/2024 | SMU (11-3,8-1) | 34 | at | Louisville | 27 | |||
| 10/12/2024 | Louisville | 24 | at | Virginia (5-7,3-5) | 20 | |||
| 10/19/2024 | Miami-Florida (10-3,6-2) | 52 | at | Louisville | 45 | |||
| 10/25/2024 | Louisville | 31 | at | Boston College (7-6,4-4) | 27 | |||
| 11/2/2024 | Louisville | 33 | at | Clemson (10-4,8-1) | 21 | |||
| 11/16/2024 | Louisville | 35 | at | Stanford (3-9,2-6) | 38 | |||
| 11/23/2024 | Pittsburgh (7-6,3-5) | 9 | at | Louisville | 37 | |||
| 11/30/2024 | Louisville | 41 | at | Kentucky (4-8) | 14 | at SEC | ||
| 12/31/2024 | Louisville | 35 | vs | Washington (6-7) | 34 | Sun Bowl - El Paso TX | vs B10 |
| vs Louisville | vs Other Opponents | Louisville compared to OOs | |
| Record: | 4-9 | 93-65 | |
| Points Scored: | 24.08 | 30.84 | 6.76 |
| Points Allowed: | 36.46 | 23.91 | 12.55 |
| Margin: | -12.38 | 6.93 | 19.31 |
| Total Points: | 60.54 | 54.75 | 5.79 |