| 8/31/2024 | Austin Peay (4-5) | 0 | at | Louisville | 62 | UAC (1AA) | ||
| 9/7/2024 | Jacksonville State (5-3) | 14 | at | Louisville | 49 | CUSA | ||
| 9/21/2024 | Georgia Tech (5-4,3-3) | 19 | at | Louisville | 31 | |||
| 9/28/2024 | Louisville | 24 | at | Notre Dame (7-1) | 31 | at ND | ||
| 10/5/2024 | SMU (8-1,5-0) | 34 | at | Louisville | 27 | |||
| 10/12/2024 | Louisville | 24 | at | Virginia (4-4,2-3) | 20 | |||
| 10/19/2024 | Miami-Florida (9-0,5-0) | 52 | at | Louisville | 45 | |||
| 10/25/2024 | Louisville | 31 | at | Boston College (4-4,1-3) | 27 | |||
| 11/2/2024 | Louisville | 33 | at | Clemson (6-2,5-1) | 21 | |||
| 11/16/2024 | Louisville | at | Stanford (2-7,1-5) | |||||
| 11/23/2024 | Pittsburgh (7-1,3-1) | at | Louisville | |||||
| 11/30/2024 | Louisville | at | Kentucky (3-6) | at SEC |
| vs Louisville | vs Other Opponents | Louisville compared to OOs | |
| Record: | 3-6 | 61-32 | |
| Points Scored: | 24.22 | 32.41 | 8.19 |
| Points Allowed: | 36.22 | 22.99 | 13.23 |
| Margin: | -12.00 | 9.42 | 21.42 |
| Total Points: | 60.44 | 55.40 | 5.04 |