| 8/30/2024 | Elon (6-6) | 3 | at | Duke | 26 | CAAF (1AA) | ||
| 9/6/2024 | Duke | 26 | at | Northwestern (4-8) | 20 | at B10 | ||
| 9/14/2024 | Connecticut (9-4) | 21 | at | Duke | 26 | Ind | ||
| 9/21/2024 | Duke | 45 | at | Middle Tenn State (3-9) | 17 | at CUSA | ||
| 9/28/2024 | North Carolina (6-7,3-5) | 20 | at | Duke | 21 | |||
| 10/5/2024 | Duke | 14 | at | Georgia Tech (7-6,5-3) | 24 | |||
| 10/18/2024 | Florida State (2-10,1-7) | 16 | at | Duke | 23 | |||
| 10/26/2024 | SMU (11-3,8-1) | 28 | at | Duke | 27 | OT | ||
| 11/2/2024 | Duke | 31 | at | Miami-Florida (10-3,6-2) | 53 | |||
| 11/9/2024 | Duke | 29 | at | North Carolina State (6-7,3-5) | 19 | |||
| 11/23/2024 | Virginia Tech (6-7,4-4) | 28 | at | Duke | 31 | |||
| 11/30/2024 | Duke | 23 | at | Wake Forest (4-8,2-6) | 17 | |||
| 1/2/2025 | Duke | 20 | vs | Mississippi (10-3) | 52 | Gator Bowl - Jacksonville FL | vs SEC |
| vs Duke | vs Other Opponents | Duke compared to OOs | |
| Record: | 4-9 | 80-72 | |
| Points Scored: | 24.46 | 29.11 | 4.65 |
| Points Allowed: | 26.31 | 25.88 | 0.43 |
| Margin: | -1.85 | 3.23 | 5.08 |
| Total Points: | 50.77 | 54.99 | -4.22 |