| 8/30/2024 | Elon (3-6) | 3 | at | Duke | 26 | CAAF (1AA) | ||
| 9/6/2024 | Duke | 26 | at | Northwestern (4-5) | 20 | at B10 | ||
| 9/14/2024 | Connecticut (6-3) | 21 | at | Duke | 26 | Ind | ||
| 9/21/2024 | Duke | 45 | at | Middle Tenn State (3-6) | 17 | at CUSA | ||
| 9/28/2024 | North Carolina (5-4,2-3) | 20 | at | Duke | 21 | |||
| 10/5/2024 | Duke | 14 | at | Georgia Tech (5-4,3-3) | 24 | |||
| 10/18/2024 | Florida State (1-8,1-7) | 16 | at | Duke | 23 | |||
| 10/26/2024 | SMU (8-1,5-0) | 28 | at | Duke | 27 | OT | ||
| 11/2/2024 | Duke | 31 | at | Miami-Florida (9-0,5-0) | 53 | |||
| 11/9/2024 | Duke | at | North Carolina State (5-4,2-3) | |||||
| 11/23/2024 | Virginia Tech (5-4,3-2) | at | Duke | |||||
| 11/30/2024 | Duke | at | Wake Forest (4-4,2-2) |
| vs Duke | vs Other Opponents | Duke compared to OOs | |
| Record: | 3-6 | 55-43 | |
| Points Scored: | 22.44 | 29.07 | 6.63 |
| Points Allowed: | 26.56 | 25.42 | 1.14 |
| Margin: | -4.12 | 3.65 | 7.77 |
| Total Points: | 49.00 | 54.49 | -5.49 |