| 8/30/2024 | Elon (5-6) | 3 | at | Duke | 26 | CAAF (1AA) | ||
| 9/6/2024 | Duke | 26 | at | Northwestern (4-6) | 20 | at B10 | ||
| 9/14/2024 | Connecticut (7-3) | 21 | at | Duke | 26 | Ind | ||
| 9/21/2024 | Duke | 45 | at | Middle Tenn State (3-7) | 17 | at CUSA | ||
| 9/28/2024 | North Carolina (6-4,3-3) | 20 | at | Duke | 21 | |||
| 10/5/2024 | Duke | 14 | at | Georgia Tech (6-4,4-3) | 24 | |||
| 10/18/2024 | Florida State (1-9,1-7) | 16 | at | Duke | 23 | |||
| 10/26/2024 | SMU (9-1,6-0) | 28 | at | Duke | 27 | OT | ||
| 11/2/2024 | Duke | 31 | at | Miami-Florida (9-1,5-1) | 53 | |||
| 11/9/2024 | Duke | 29 | at | North Carolina State (5-5,2-4) | 19 | |||
| 11/23/2024 | Virginia Tech (5-5,3-3) | at | Duke | |||||
| 11/30/2024 | Duke | at | Wake Forest (4-6,2-4) |
| vs Duke | vs Other Opponents | Duke compared to OOs | |
| Record: | 3-7 | 61-50 | |
| Points Scored: | 22.10 | 28.58 | 6.48 |
| Points Allowed: | 26.80 | 26.12 | 0.68 |
| Margin: | -4.70 | 2.46 | 7.16 |
| Total Points: | 48.90 | 54.70 | -5.80 |