| 9/2/2021 | Reinhardt | 25 | at | Kennesaw St (11-2) | 35 | at BigS | ||
| 9/11/2021 | Warner U. (3-8,3-7) | 0 | at | Reinhardt | 45 | |||
| 9/18/2021 | Campbellsville (1-9,1-9) | 7 | at | Reinhardt | 52 | |||
| 9/25/2021 | Reinhardt | 33 | at | Bethel TN (7-4,7-3) | 34 | |||
| 10/2/2021 | Reinhardt | 40 | at | Ave Maria (5-6,5-5) | 16 | |||
| 10/9/2021 | Bluefield (6-5,5-5) | 35 | at | Reinhardt | 49 | |||
| 10/16/2021 | Reinhardt | 41 | at | Point (2-9,2-7) | 0 | |||
| 10/23/2021 | Faulkner (7-2,7-2) | 6 | at | Reinhardt | 14 | |||
| 10/30/2021 | Reinhardt | 63 | at | St Andrews (1-9,1-8) | 18 | |||
| 11/6/2021 | Union KY (2-7,2-7) | 7 | at | Reinhardt | 47 | |||
| 11/13/2021 | Reinhardt | 49 | at | Kentucky Christian (3-7,3-7) | 15 | |||
| 11/20/2021 | Keiser (9-3,9-3) | 16 | at | Reinhardt | 13 |
| vs Reinhardt | vs Other Opponents | Reinhardt compared to OOs | |
| Record: | 3-9 | 54-62 | |
| Points Scored: | 15.75 | 27.68 | 11.93 |
| Points Allowed: | 39.25 | 32.66 | 6.59 |
| Margin: | -23.50 | -4.98 | 18.52 |
| Total Points: | 55.00 | 60.34 | -5.34 |