| 9/11/2021 | St Vincent | 34 | at | Bluffton (4-6) | 14 | at HCA | ||
| 9/18/2021 | Geneva (4-6,4-5) | 42 | at | St Vincent | 24 | |||
| 9/25/2021 | St Vincent | 41 | at | Thiel (0-10,0-9) | 7 | |||
| 10/2/2021 | Case Western Reserve (6-4,5-4) | 40 | at | St Vincent | 42 | |||
| 10/9/2021 | St Vincent | 22 | at | Washington & Jefferson (8-3,7-2) | 63 | |||
| 10/16/2021 | Grove City (8-3,6-3) | 41 | at | St Vincent | 29 | |||
| 10/23/2021 | St Vincent | 38 | at | Waynesburg (2-8,2-7) | 7 | |||
| 10/30/2021 | Carnegie Mellon (8-2,8-1) | 34 | at | St Vincent | 7 | |||
| 11/6/2021 | St Vincent | 6 | at | Westminster PA (8-3,8-1) | 41 | |||
| 11/13/2021 | Bethany WV (1-9,1-8) | 7 | at | St Vincent | 52 | |||
| 11/20/2021 | St Vincent | 19 | at | Fairleigh Dickinson-Florham (7-4) | 38 | at MidAC |
| vs St Vincent | vs Other Opponents | St Vincent compared to OOs | |
| Record: | 6-5 | 50-53 | |
| Points Scored: | 30.36 | 24.92 | -5.44 |
| Points Allowed: | 28.55 | 26.70 | 1.85 |
| Margin: | 1.81 | -1.78 | -3.59 |
| Total Points: | 58.91 | 51.62 | 7.29 |