| 9/4/2021 | Grove City | 39 | at | Juniata (1-9) | 14 | at Cen | ||
| 9/11/2021 | Bethany WV (1-9,1-8) | 15 | at | Grove City | 48 | |||
| 9/18/2021 | Carnegie Mellon (8-2,8-1) | 6 | at | Grove City | 13 | |||
| 9/25/2021 | Grove City | 32 | at | Westminster PA (8-3,8-1) | 33 | |||
| 10/2/2021 | Grove City | 38 | at | Waynesburg (2-8,2-7) | 0 | |||
| 10/9/2021 | Geneva (4-6,4-5) | 7 | at | Grove City | 56 | |||
| 10/16/2021 | Grove City | 41 | at | St Vincent (5-6,4-5) | 29 | |||
| 10/30/2021 | Washington & Jefferson (8-3,7-2) | 28 | at | Grove City | 24 | |||
| 11/6/2021 | Grove City | 21 | at | Case Western Reserve (6-4,5-4) | 35 | |||
| 11/13/2021 | Grove City | 56 | at | Thiel (0-10,0-9) | 0 | |||
| 11/20/2021 | Utica (6-5) | 7 | at | Grove City | 49 | E8 |
| vs Grove City | vs Other Opponents | Grove City compared to OOs | |
| Record: | 3-8 | 46-57 | |
| Points Scored: | 15.82 | 23.84 | 8.02 |
| Points Allowed: | 37.91 | 28.05 | 9.86 |
| Margin: | -22.09 | -4.21 | 17.88 |
| Total Points: | 53.73 | 51.89 | 1.84 |