| 9/4/2021 | Ohio Wesleyan (8-2) | 32 | at | Otterbein | 28 | NCA | ||
| 9/11/2021 | Baldwin-Wallace (8-2,7-2) | 41 | at | Otterbein | 10 | |||
| 9/18/2021 | John Carroll (7-3,7-2) | 41 | at | Otterbein | 17 | |||
| 9/25/2021 | Otterbein | 7 | at | Ohio Northern (4-6,3-6) | 56 | |||
| 10/2/2021 | Otterbein | 0 | at | Mount Union (13-1,9-0) | 55 | |||
| 10/16/2021 | Otterbein | 19 | at | Heidelberg (7-2,6-2) | 52 | |||
| 10/23/2021 | Muskingum (5-5,4-5) | 31 | at | Otterbein | 14 | |||
| 10/30/2021 | Otterbein | 38 | at | Capital (2-8,1-8) | 33 | |||
| 11/6/2021 | Otterbein | 7 | at | Marietta (4-6,4-5) | 56 | |||
| 11/13/2021 | Wilmington (2-7,2-6) | 37 | at | Otterbein | 33 |
| vs Otterbein | vs Other Opponents | Otterbein compared to OOs | |
| Record: | 9-1 | 51-41 | |
| Points Scored: | 43.40 | 29.12 | -14.28 |
| Points Allowed: | 17.30 | 25.13 | -7.83 |
| Margin: | 26.10 | 3.99 | -22.11 |
| Total Points: | 60.70 | 54.25 | 6.45 |