| 9/4/2021 | Albion | 36 | at | Mt St Joseph (6-4) | 20 | at HCA | ||
| 9/11/2021 | Albion | 51 | at | Defiance (1-9) | 0 | at HCA | ||
| 9/18/2021 | Hanover (5-5) | 14 | at | Albion | 24 | HCA | ||
| 9/25/2021 | Wisconsin-Eau Claire (3-7) | 20 | at | Albion | 23 | WIAC | ||
| 10/9/2021 | Albion | 7 | at | Adrian (5-5,4-3) | 21 | |||
| 10/16/2021 | Albion | 49 | at | Kalamazoo (1-9,0-6) | 0 | |||
| 10/23/2021 | Olivet (7-3,4-3) | 17 | at | Albion | 38 | |||
| 10/30/2021 | Trine (6-4,4-2) | 24 | at | Albion | 31 | |||
| 11/6/2021 | Albion | 41 | at | Hope (8-2,5-1) | 38 | |||
| 11/13/2021 | Alma (5-5,1-5) | 7 | at | Albion | 34 | |||
| 11/20/2021 | Wisconsin-La Crosse (9-3) | 58 | at | Albion | 23 | WIAC |
| vs Albion | vs Other Opponents | Albion compared to OOs | |
| Record: | 2-9 | 54-47 | |
| Points Scored: | 19.91 | 27.78 | 7.87 |
| Points Allowed: | 32.45 | 24.16 | 8.29 |
| Margin: | -12.54 | 3.62 | 16.16 |
| Total Points: | 52.36 | 51.94 | 0.42 |