| 9/4/2021 | Heidelberg (7-2) | 48 | at | Adrian | 20 | OAC | ||
| 9/11/2021 | Adrian | 14 | at | Hanover (5-5) | 21 | at HCA | ||
| 9/18/2021 | Greenville (8-3) | 28 | at | Adrian | 41 | UMWAC | ||
| 9/25/2021 | Adrian | 56 | at | Finlandia (0-9,0-2) | 6 | |||
| 10/2/2021 | Adrian | 20 | at | Trine (6-4,4-2) | 36 | |||
| 10/9/2021 | Albion (9-2,5-1) | 7 | at | Adrian | 21 | |||
| 10/16/2021 | Alma (5-5,1-5) | 21 | at | Adrian | 36 | |||
| 10/23/2021 | Adrian | 7 | at | Hope (8-2,5-1) | 19 | |||
| 11/6/2021 | Olivet (7-3,4-3) | 35 | at | Adrian | 28 | |||
| 11/13/2021 | Adrian | 33 | at | Kalamazoo (1-9,0-6) | 21 |
| vs Adrian | vs Other Opponents | Adrian compared to OOs | |
| Record: | 5-5 | 51-39 | |
| Points Scored: | 24.20 | 28.92 | 4.72 |
| Points Allowed: | 27.60 | 24.30 | 3.30 |
| Margin: | -3.40 | 4.62 | 8.02 |
| Total Points: | 51.80 | 53.22 | -1.42 |