| 9/5/2015 | SE Missouri State | 3 | at | Missouri (5-7) | 34 | at SEC | ||
| 9/12/2015 | Southern Illinois (3-8) | 24 | at | SE Missouri State | 27 | MVC | ||
| 9/19/2015 | SE Missouri State | 28 | at | Indiana State (5-6) | 29 | at MVC | ||
| 9/26/2015 | Shorter (2-8) | 26 | at | SE Missouri State | 21 | GSC (D2) | ||
| 10/3/2015 | Murray State (3-8,2-6) | 10 | at | SE Missouri State | 27 | |||
| 10/10/2015 | SE Missouri State | 28 | at | Eastern Illinois (7-5,7-1) | 33 | |||
| 10/17/2015 | Eastern Kentucky (6-5,5-3) | 27 | at | SE Missouri State | 10 | |||
| 10/31/2015 | Tennessee Tech (4-7,3-5) | 17 | at | SE Missouri State | 38 | |||
| 11/7/2015 | SE Missouri State | 44 | at | Austin Peay (0-11,0-8) | 15 | |||
| 11/14/2015 | SE Missouri State | 28 | at | Jacksonville State (13-2,8-0) | 56 | |||
| 11/21/2015 | Tennessee-Martin (7-4,6-2) | 28 | at | SE Missouri State | 25 |
| vs SE Missouri State | vs Other Opponents | SE Missouri State compared to OOs | |
| Record: | 7-4 | 48-67 | |
| Points Scored: | 27.18 | 26.70 | -0.48 |
| Points Allowed: | 25.36 | 29.86 | -4.50 |
| Margin: | 1.82 | -3.16 | -4.98 |
| Total Points: | 52.54 | 56.56 | -4.02 |