| 9/5/2015 | Southern Illinois (3-8) | 47 | at | Indiana | 48 | MVC (1AA) | ||
| 9/12/2015 | Florida Intl (5-7) | 22 | at | Indiana | 36 | CUSA | ||
| 9/19/2015 | Western Kentucky (12-2) | 35 | at | Indiana | 38 | CUSA | ||
| 9/26/2015 | Indiana | 31 | at | Wake Forest (3-9) | 24 | at ACC | ||
| 10/3/2015 | Ohio State (12-1,7-1) | 34 | at | Indiana | 27 | |||
| 10/10/2015 | Indiana | 7 | at | Penn State (7-6,4-4) | 29 | |||
| 10/17/2015 | Rutgers (4-8,1-7) | 55 | at | Indiana | 52 | |||
| 10/24/2015 | Indiana | 26 | at | Michigan State (12-2,8-1) | 52 | |||
| 11/7/2015 | Iowa (12-2,8-1) | 35 | at | Indiana | 27 | |||
| 11/14/2015 | Michigan (10-3,6-2) | 48 | at | Indiana | 41 | 2OT | ||
| 11/21/2015 | Indiana | 47 | at | Maryland (3-9,1-7) | 28 | |||
| 11/28/2015 | Indiana | 54 | at | Purdue (2-10,1-7) | 36 | |||
| 12/26/2015 | Indiana | 41 | vs | Duke (8-5) | 44 | OT | Pinstripe Bowl (New York NY) | vs ACC |
| vs Indiana | vs Other Opponents | Indiana compared to OOs | |
| Record: | 7-6 | 86-66 | |
| Points Scored: | 37.62 | 28.93 | -8.69 |
| Points Allowed: | 36.54 | 25.03 | 11.51 |
| Margin: | 1.08 | 3.90 | 2.82 |
| Total Points: | 74.16 | 53.96 | 20.20 |