9/3/2015 | LIU Post | 41 | at | East Stroudsburg | 40 | | | NE10 |
| St Joseph's | 30 | at | Edinboro | 10 | | | GLV |
| Clarion | 40 | at | Lock Haven | 13 | | | |
| Ursinus | 17 | at | Millersville | 9 | 5OT | | Cen (D3) |
| Lenoir-Rhyne | 41 | at | West Chester | 28 | | | SAC |
9/5/2015 | Stonehill | 27 | at | Bloomsburg | 10 | | | NE10 |
| Lincoln PA | 29 | at | Cheyney | 22 | | | CIAA |
| Assumption | 41 | at | Kutztown | 37 | | | NE10 |
| Bentley | 20 | at | Mercyhurst | 35 | | | NE10 |
| Slippery Rock | 39 | at | New Haven | 13 | | | @ NE10 |
| Seton Hill | 14 | at | Shippensburg | 64 | | | |
| Gannon | 26 | at | Southern Connecticut | 22 | | | @ NE10 |
| California PA | 35 | at | Virginia State | 16 | | | @ CIAA |
9/10/2015 | Millersville | 21 | at | Clarion | 27 | | | |
9/12/2015 | Bloomsburg | 20 | at | California PA | 13 | | | |
| Shippensburg | 20 | at | Edinboro | 13 | | | |
| Cheyney | 6 | at | Gannon | 44 | | | |
| Kutztown | 34 | at | Indiana PA | 33 | | | |
| West Chester | 35 | at | Mercyhurst | 37 | | | |
| Lock Haven | 10 | at | Seton Hill | 27 | | | |
| East Stroudsburg | 9 | at | Slippery Rock | 34 | | | |
9/19/2015 | Mercyhurst | 20 | at | Bloomsburg | 14 | | | |
| Shippensburg | 26 | at | California PA | 34 | | | |
| Cheyney | 6 | at | Clarion | 59 | | | |
| Edinboro | 12 | at | East Stroudsburg | 56 | | | |
| Lock Haven | 13 | at | Indiana PA | 38 | | | |
| Gannon | 66 | at | Kutztown | 31 | | | |
| Millersville | 0 | at | Slippery Rock | 75 | | | |
| Seton Hill | 38 | at | West Chester | 48 | | | |
9/26/2015 | Kutztown | 34 | at | Cheyney | 0 | | | |
| California PA | 37 | at | Edinboro | 30 | | | |
| Clarion | 47 | at | Gannon | 31 | | | |
| East Stroudsburg | 37 | at | Lock Haven | 34 | | | |
| Indiana PA | 35 | at | Mercyhurst | 14 | | | |
| West Chester | 48 | at | Millersville | 3 | | | |
| Slippery Rock | 38 | at | Seton Hill | 41 | | | |
| Bloomsburg | 17 | at | Shippensburg | 6 | | | |
10/3/2015 | Cheyney | 0 | at | Bloomsburg | 63 | | | |
| Seton Hill | 34 | at | California PA | 38 | | | |
| Mercyhurst | 27 | at | Clarion | 41 | | | |
| Shippensburg | 69 | at | East Stroudsburg | 67 | 4OT | | |
| Slippery Rock | 41 | at | Gannon | 14 | | | |
| Edinboro | 21 | at | Indiana PA | 42 | | | |
| Millersville | 14 | at | Kutztown | 47 | | | |
| West Chester | 33 | at | Lock Haven | 9 | | | |
10/10/2015 | East Stroudsburg | 69 | at | Cheyney | 7 | | | |
| Clarion | 36 | at | Edinboro | 23 | | | |
| Gannon | 16 | at | Mercyhurst | 13 | | | |
| Bloomsburg | 41 | at | Millersville | 20 | | | |
| Indiana PA | 47 | at | Seton Hill | 10 | | | |
| Lock Haven | 34 | at | Shippensburg | 44 | | | |
| California PA | 21 | at | Slippery Rock | 56 | | | |
| Kutztown | 14 | at | West Chester | 44 | | | |
10/15/2015 | Edinboro | 42 | at | Gannon | 49 | | | |
10/17/2015 | Kutztown | 21 | at | Bloomsburg | 27 | OT | | |
| Seton Hill | 29 | at | Clarion | 44 | | | |
| Millersville | 2 | at | East Stroudsburg | 34 | | | |
| California PA | 15 | at | Indiana PA | 20 | | | |
| Cheyney | 20 | at | Lock Haven | 56 | | | |
| Slippery Rock | 35 | at | Mercyhurst | 24 | | | |
| West Chester | 11 | at | Shippensburg | 27 | | | |
10/22/2015 | Mercyhurst | 38 | at | Edinboro | 28 | | | |
10/24/2015 | Clarion | 28 | at | California PA | 42 | | | |
| Shippensburg | 70 | at | Cheyney | 7 | | | |
| East Stroudsburg | 17 | at | Kutztown | 63 | | | |
| Lock Haven | 36 | at | Millersville | 28 | | | |
| Gannon | 43 | at | Seton Hill | 28 | | | |
| Indiana PA | 39 | at | Slippery Rock | 40 | | | |
| Bloomsburg | 22 | at | West Chester | 33 | | | |
10/31/2015 | West Chester | 41 | at | Cheyney | 20 | | | |
| Indiana PA | 28 | at | Clarion | 14 | | | |
| Bloomsburg | 34 | at | East Stroudsburg | 35 | | | |
| Slippery Rock | 52 | at | Edinboro | 10 | | | |
| California PA | 42 | at | Gannon | 21 | | | |
| Kutztown | 34 | at | Lock Haven | 20 | | | |
| Seton Hill | 13 | at | Mercyhurst | 41 | | | |
| Millersville | 7 | at | Shippensburg | 63 | | | |
11/7/2015 | Lock Haven | 25 | at | Bloomsburg | 31 | 2OT | | |
| Mercyhurst | 21 | at | California PA | 31 | | | |
| Gannon | 14 | at | Indiana PA | 26 | | | |
| Shippensburg | 27 | at | Kutztown | 51 | | | |
| Cheyney | 6 | at | Millersville | 26 | | | |
| Edinboro | 23 | at | Seton Hill | 44 | | | |
| Clarion | 13 | at | Slippery Rock | 65 | | | |
| East Stroudsburg | 27 | at | West Chester | 41 | | | |
11/14/2015 | Seton Hill | 14 | at | Bloomsburg | 17 | | | |
| Gannon | 37 | at | East Stroudsburg | 49 | | | |
| Cheyney | 0 | at | Indiana PA | 62 | | | |
| Clarion | 17 | at | Kutztown | 45 | | | |
| California PA | 56 | at | Lock Haven | 24 | | | |
| Edinboro | 21 | at | Millersville | 31 | | | |
| Mercyhurst | 20 | at | Shippensburg | 69 | | | |
| Slippery Rock | 61 | at | West Chester | 12 | | | |
11/21/2015 | Indiana PA | 47 | at | Charleston WV | 21 | | NCAA D2 Championship - First Round | @ MtnE |
| Virginia Union | 21 | at | Slippery Rock | 40 | | NCAA D2 Championship - First Round | CIAA |
11/28/2015 | Indiana PA | 13 | at | Shepherd | 17 | | NCAA D2 Championship - Second Round | @ MtnE |
| Assumption | 39 | at | Slippery Rock | 41 | | NCAA D2 Championship - Second Round | NE10 |
12/5/2015 | Slippery Rock | 16 | at | Shepherd | 28 | | NCAA D2 Quarterfinal | @ MtnE |