| 9/4/2015 | Gettysburg | 49 | at | Bridgewater VA | 10 | Cen | ||
| Averett | 35 | at | Washington and Lee | 63 | USASC | |||
| 9/5/2015 | Ferrum | 7 | at | Emory & Henry | 55 | USASC | ||
| Guilford | 77 | at | Greensboro | 13 | @ USASC | |||
| Wabash | 35 | at | Hampden-Sydney | 3 | NCA | |||
| Catholic | 34 | at | McDaniel | 33 | @ Cen | |||
| Johns Hopkins | 52 | at | Randolph-Macon | 17 | Cen | |||
| Gallaudet | 6 | at | Shenandoah | 51 | ECFC | |||
| 9/12/2015 | Randolph-Macon | 49 | at | Averett | 28 | @ USASC | ||
| Rochester | 45 | at | Catholic | 28 | LL | |||
| Hampden-Sydney | 24 | at | Christopher Newport | 9 | @ NJAC | |||
| Shenandoah | 42 | at | Ferrum | 27 | @ USASC | |||
| Bridgewater VA | 38 | at | Greensboro | 21 | @ USASC | |||
| Guilford | 55 | at | Methodist | 7 | @ USASC | |||
| Sewanee | 10 | at | Washington and Lee | 28 | SAA | |||
| 9/19/2015 | Apprentice | 14 | at | Bridgewater VA | 34 | D3Ind | ||
| Coast Guard | 24 | at | Catholic | 40 | NEF | |||
| Maryville | 30 | at | Emory & Henry | 13 | USASC | |||
| Hampden-Sydney | 55 | at | Ferrum | 24 | @ USASC | |||
| Averett | 21 | at | Guilford | 58 | USASC | |||
| Randolph-Macon | 24 | at | Methodist | 31 | @ USASC | |||
| Shenandoah | 30 | at | North Carolina Wesleyan | 17 | @ USASC | |||
| 9/25/2015 | Apprentice | 21 | at | Washington and Lee | 56 | D3Ind | ||
| 9/26/2015 | Emory & Henry | 27 | at | East Tennessee St | 24 | @ IndFCS (1AA) | ||
| 10/3/2015 | Catholic | 21 | at | Hampden-Sydney | 38 | |||
| Emory & Henry | 31 | at | Randolph-Macon | 21 | ||||
| Bridgewater VA | 39 | at | Shenandoah | 21 | ||||
| Guilford | 17 | at | Washington and Lee | 20 | ||||
| 10/10/2015 | Randolph-Macon | 20 | at | Catholic | 28 | |||
| Bridgewater VA | 7 | at | Emory & Henry | 31 | ||||
| Shenandoah | 38 | at | Guilford | 55 | ||||
| Washington and Lee | 35 | at | Hampden-Sydney | 28 | ||||
| 10/17/2015 | Guilford | 23 | at | Bridgewater VA | 20 | |||
| Hampden-Sydney | 31 | at | Emory & Henry | 28 | ||||
| Washington and Lee | 21 | at | Randolph-Macon | 17 | ||||
| Catholic | 17 | at | Shenandoah | 34 | ||||
| 10/24/2015 | Emory & Henry | 44 | at | Catholic | 24 | |||
| Randolph-Macon | 21 | at | Guilford | 41 | ||||
| Shenandoah | 33 | at | Hampden-Sydney | 38 | ||||
| Bridgewater VA | 23 | at | Washington and Lee | 45 | ||||
| 10/31/2015 | Guilford | 52 | at | Catholic | 49 | |||
| Washington and Lee | 42 | at | Emory & Henry | 14 | ||||
| Bridgewater VA | 3 | at | Hampden-Sydney | 27 | ||||
| Shenandoah | 13 | at | Randolph-Macon | 31 | ||||
| 11/7/2015 | Randolph-Macon | 35 | at | Bridgewater VA | 14 | |||
| Hampden-Sydney | 20 | at | Guilford | 33 | ||||
| Emory & Henry | 54 | at | Shenandoah | 21 | ||||
| Catholic | 33 | at | Washington and Lee | 52 | ||||
| 11/14/2015 | Catholic | 13 | at | Bridgewater VA | 45 | |||
| Emory & Henry | 30 | at | Guilford | 41 | ||||
| Hampden-Sydney | 9 | at | Randolph-Macon | 14 | ||||
| Washington and Lee | 34 | at | Shenandoah | 21 | ||||
| 11/21/2015 | Washington and Lee | 21 | at | Thomas More | 51 | NCAA D3 Championship - First Round | @ TPAC |