9/5/2015 | Wittenberg | 38 | at | Capital | 27 | | | @ OAC |
| Marietta | 14 | at | Denison | 41 | | | OAC |
| Wabash | 35 | at | Hampden-Sydney | 3 | | | @ ODC |
| Westminster PA | 17 | at | Hiram | 9 | | | TPAC |
| Brockport State | 44 | at | Oberlin | 7 | | | E8 |
| Mary Hardin-Baylor | 42 | at | Ohio Wesleyan | 3 | | | ASWC |
| Kenyon | 21 | at | Sewanee | 31 | | | @ SAA |
| Allegheny | 21 | at | Thiel | 37 | | | @ TPAC |
| Washington & Jefferson | 56 | at | Wooster | 10 | | | TPAC |
9/12/2015 | Wooster | 28 | at | Allegheny | 13 | | | |
| DePauw | 53 | at | Earlham | 0 | | | @ HCA |
| Kenyon | 24 | at | Oberlin | 28 | | | |
9/19/2015 | Wabash | 54 | at | Allegheny | 0 | | | |
| Oberlin | 0 | at | Denison | 45 | | | |
| Wooster | 20 | at | DePauw | 49 | | | |
| Hiram | 17 | at | Kenyon | 34 | | | |
| Ohio Wesleyan | 21 | at | Wittenberg | 42 | | | |
9/26/2015 | Kenyon | 32 | at | Allegheny | 17 | | | |
| DePauw | 45 | at | Hiram | 7 | | | |
| Oberlin | 42 | at | Ohio Wesleyan | 55 | | | |
| Wittenberg | 14 | at | Wabash | 42 | | | |
| Denison | 31 | at | Wooster | 17 | | | |
10/3/2015 | DePauw | 38 | at | Kenyon | 16 | | | |
| Allegheny | 9 | at | Oberlin | 48 | | | |
| Denison | 10 | at | Ohio Wesleyan | 9 | | | |
| Hiram | 0 | at | Wabash | 38 | | | |
| Wooster | 0 | at | Wittenberg | 24 | | | |
10/10/2015 | Hiram | 6 | at | Denison | 17 | | | |
| Wittenberg | 30 | at | DePauw | 35 | | | |
| Ohio Wesleyan | 23 | at | Kenyon | 20 | 2OT | | |
| Wabash | 55 | at | Oberlin | 18 | | | |
10/17/2015 | Allegheny | 0 | at | DePauw | 50 | | | |
| Ohio Wesleyan | 31 | at | Hiram | 32 | | | |
| Kenyon | 0 | at | Wabash | 35 | | | |
| Denison | 14 | at | Wittenberg | 45 | | | |
| Oberlin | 28 | at | Wooster | 23 | | | |
10/24/2015 | Denison | 33 | at | Allegheny | 7 | | | |
| Wittenberg | 27 | at | Hiram | 10 | | | |
| DePauw | 22 | at | Ohio Wesleyan | 27 | | | |
| Wabash | 55 | at | Wooster | 7 | | | |
10/31/2015 | Hiram | 43 | at | Allegheny | 13 | | | |
| DePauw | 31 | at | Denison | 29 | | | |
| Wooster | 49 | at | Kenyon | 42 | | | |
| Ohio Wesleyan | 10 | at | Wabash | 34 | | | |
| Oberlin | 2 | at | Wittenberg | 62 | | | |
11/7/2015 | Oberlin | 0 | at | DePauw | 53 | | | |
| Wooster | 36 | at | Hiram | 40 | | | |
| Wittenberg | 45 | at | Kenyon | 21 | | | |
| Allegheny | 9 | at | Ohio Wesleyan | 39 | | | |
| Denison | 7 | at | Wabash | 38 | | | |
11/14/2015 | Kenyon | 17 | at | Denison | 30 | | | |
| Wabash | 45 | at | DePauw | 17 | | | |
| Hiram | 24 | at | Oberlin | 21 | | | |
| Allegheny | 0 | at | Wittenberg | 63 | | | |
| Ohio Wesleyan | 59 | at | Wooster | 28 | | | |
11/21/2015 | Albion | 14 | at | Wabash | 35 | | NCAA D3 Championship - First Round | MIAA |
11/28/2015 | Thomas More | 27 | at | Wabash | 33 | | NCAA D3 Championship - Second Round | TPAC |
12/5/2015 | Wabash | 7 | at | St Thomas | 38 | | NCAA D3 Quarterfinal | @ MIA |