| 9/4/2015 | St Lawrence | 20 | at | Morrisville | 28 | @ E8 | ||
| MIT | 28 | at | Worcester Polytechnic | 31 | NEF | |||
| 9/5/2015 | Hobart | 29 | at | Dickinson | 7 | @ Cen | ||
| Norwich | 0 | at | Rensselaer | 37 | ECFC | |||
| Ithaca | 38 | at | Union NY | 23 | E8 | |||
| Springfield | 14 | at | Western New England | 34 | @ NEF | |||
| 9/11/2015 | UMass Dartmouth | 17 | at | Springfield | 35 | MSCAC | ||
| Worcester Polytechnic | 27 | at | Worcester State | 13 | @ MSCAC | |||
| 9/12/2015 | Rensselaer | 20 | at | Alfred | 32 | @ E8 | ||
| Rochester | 45 | at | Catholic | 28 | @ ODC | |||
| Endicott | 17 | at | Hobart | 28 | NEF | |||
| Coast Guard | 3 | at | Merchant Marine | 14 | NEF | |||
| St Lawrence | 42 | at | Norwich | 28 | @ ECFC | |||
| Union NY | 33 | at | Western Connecticut | 48 | @ MSCAC | |||
| 9/18/2015 | SUNY-Maritime | 24 | at | Merchant Marine | 14 | ECFC | ||
| 9/19/2015 | Hobart | 6 | at | Ithaca | 24 | @ E8 | ||
| Springfield | 38 | at | Mount Ida | 10 | @ ECFC | |||
| Alfred State | 0 | at | Rochester | 61 | D3Ind | |||
| MIT | 7 | at | Rensselaer | 42 | NEF | |||
| Endicott | 9 | at | St Lawrence | 34 | NEF | |||
| Union NY | 14 | at | Western New England | 41 | @ NEF | |||
| Norwich | 10 | at | Worcester Polytechnic | 27 | ECFC | |||
| 9/26/2015 | Hobart | 30 | at | Merchant Marine | 15 | |||
| Springfield | 3 | at | Rochester | 29 | ||||
| St Lawrence | 42 | at | Union NY | 23 | ||||
| Rensselaer | 28 | at | Worcester Polytechnic | 21 | ||||
| 10/3/2015 | Worcester Polytechnic | 7 | at | Hobart | 37 | |||
| Merchant Marine | 7 | at | Rensselaer | 27 | ||||
| Union NY | 17 | at | Springfield | 20 | ||||
| Rochester | 0 | at | St Lawrence | 20 | ||||
| 10/10/2015 | Merchant Marine | 17 | at | Rochester | 24 | |||
| Hobart | 13 | at | Springfield | 35 | ||||
| Rensselaer | 21 | at | St Lawrence | 24 | ||||
| Worcester Polytechnic | 29 | at | Union NY | 21 | ||||
| 10/17/2015 | Springfield | 21 | at | Merchant Marine | 22 | |||
| Rochester | 21 | at | Rensselaer | 35 | ||||
| 10/23/2015 | Merchant Marine | 8 | at | Worcester Polytechnic | 38 | |||
| 10/24/2015 | Rensselaer | 21 | at | Hobart | 20 | |||
| Union NY | 30 | at | Rochester | 33 | ||||
| St Lawrence | 38 | at | Springfield | 21 | ||||
| 10/31/2015 | Worcester Polytechnic | 21 | at | St Lawrence | 42 | |||
| Hobart | 52 | at | Union NY | 14 | ||||
| 11/7/2015 | St Lawrence | 17 | at | Hobart | 19 | |||
| Union NY | 14 | at | Merchant Marine | 24 | ||||
| Springfield | 14 | at | Rensselaer | 17 | ||||
| Rochester | 34 | at | Worcester Polytechnic | 35 | ||||
| 11/14/2015 | Hobart | 42 | at | Rochester | 20 | |||
| Worcester Polytechnic | 19 | at | Springfield | 17 | ||||
| Merchant Marine | 14 | at | St Lawrence | 21 | ||||
| Rensselaer | 23 | at | Union NY | 10 | ||||
| 11/21/2015 | St Lawrence | 23 | at | Mount Union | 55 | NCAA D3 Championship - First Round | @ OAC |