| 9/4/2015 | Luther | 19 | at | Wisconsin-La Crosse | 26 | @ WIAC | ||
| 9/5/2015 | Ill. Benedictine | 21 | at | Central IA | 19 | NAC | ||
| Wheaton | 52 | at | Coe | 14 | CCIW | |||
| Loras | 17 | at | Elmhurst | 31 | @ CCIW | |||
| Wisconsin-River Falls | 21 | at | Simpson | 28 | WIAC | |||
| Dubuque | 9 | at | St John's MN | 45 | @ MIA | |||
| Buena Vista | 13 | at | Wisconsin-Platteville | 49 | @ WIAC | |||
| Augsburg | 27 | at | Wartburg | 35 | MIA | |||
| 9/12/2015 | Wartburg | 24 | at | Bethel MN | 14 | @ MIA | ||
| Cornell IA | 3 | at | Coe | 50 | MidW | |||
| Wisconsin-Platteville | 31 | at | Dubuque | 7 | WIAC | |||
| Wisconsin-Stout | 52 | at | Loras | 42 | WIAC | |||
| St Olaf | 16 | at | Luther | 34 | MIA | |||
| Central IA | 23 | at | Monmouth IL | 17 | OT | @ MidW | ||
| Buena Vista | 7 | at | St John's MN | 56 | @ MIA | |||
| 9/19/2015 | Luther | 56 | at | Grinnell | 0 | @ MidW | ||
| Simpson | 7 | at | Illinois Wesleyan | 49 | @ CCIW | |||
| Augustana IL | 52 | at | Loras | 56 | CCIW | |||
| Central IA | 65 | at | Maranatha Baptist | 0 | @ D3Ind | |||
| Dubuque | 31 | at | Pacific | 29 | @ NWC | |||
| Coe | 31 | at | Wisconsin-Stevens Point | 34 | @ WIAC | |||
| Wartburg | 41 | at | Wisconsin-Stout | 33 | @ WIAC | |||
| 9/26/2015 | Waldorf | 10 | at | Buena Vista | 14 | NSAA (NAIA) | ||
| Elmhurst | 31 | at | Simpson | 12 | CCIW | |||
| 10/3/2015 | Luther | 14 | at | Dubuque | 16 | |||
| Coe | 30 | at | Loras | 27 | ||||
| Buena Vista | 13 | at | Simpson | 43 | ||||
| Central IA | 13 | at | Wartburg | 21 | ||||
| 10/10/2015 | Loras | 48 | at | Buena Vista | 41 | |||
| Luther | 10 | at | Central IA | 45 | ||||
| Dubuque | 31 | at | Simpson | 24 | ||||
| Coe | 14 | at | Wartburg | 31 | ||||
| 10/17/2015 | Simpson | 18 | at | Coe | 15 | |||
| Wartburg | 13 | at | Dubuque | 45 | ||||
| Central IA | 48 | at | Loras | 55 | ||||
| Buena Vista | 34 | at | Luther | 41 | ||||
| 10/24/2015 | Dubuque | 44 | at | Buena Vista | 13 | |||
| Coe | 13 | at | Central IA | 27 | ||||
| Simpson | 9 | at | Loras | 27 | ||||
| Wartburg | 47 | at | Luther | 7 | ||||
| 10/31/2015 | Luther | 22 | at | Coe | 44 | |||
| Loras | 7 | at | Dubuque | 42 | ||||
| Central IA | 31 | at | Simpson | 24 | ||||
| Buena Vista | 0 | at | Wartburg | 55 | ||||
| 11/7/2015 | Buena Vista | 23 | at | Central IA | 38 | |||
| Dubuque | 37 | at | Coe | 21 | ||||
| Loras | 21 | at | Luther | 31 | ||||
| Simpson | 45 | at | Wartburg | 51 | ||||
| 11/14/2015 | Coe | 52 | at | Buena Vista | 14 | |||
| Central IA | 16 | at | Dubuque | 38 | ||||
| Wartburg | 49 | at | Loras | 34 | ||||
| Simpson | 42 | at | Luther | 28 | ||||
| 11/21/2015 | Dubuque | 7 | at | St John's MN | 51 | NCAA D3 Championship - First Round | @ MIA |