| 9/3/2015 | Panhandle State | 31 | at | Angelo State | 52 | @ LSC | ||
| North Greenville | 14 | at | Charleston Southern | 41 | @ BigS (1AA) | |||
| Kentucky Wesleyan | 12 | at | Murray State | 52 | @ OVC (1AA) | |||
| Winston-Salem State | 7 | at | UNC Pembroke | 17 | CIAA | |||
| 9/5/2015 | Central State | 14 | at | Alderson-Broaddus | 22 | SIAC | ||
| 9/12/2015 | St Joseph's | 0 | at | Alderson-Broaddus | 19 | GLV | ||
| UNC Pembroke | 14 | at | Fayetteville State | 10 | @ CIAA | |||
| Panhandle State | 20 | at | Fort Lewis | 41 | @ RMAC | |||
| Kentucky Wesleyan | 34 | at | Limestone | 39 | ||||
| Lenoir-Rhyne | 13 | at | North Greenville | 35 | SAC | |||
| 9/19/2015 | Kentucky Wesleyan | 18 | at | Delta State | 51 | @ GSC | ||
| Alderson-Broaddus | 28 | at | Lincoln PA | 24 | @ CIAA | |||
| Limestone | 26 | at | Mars Hill | 36 | @ SAC | |||
| North Greenville | 6 | at | Newberry | 31 | @ SAC | |||
| Langston | 35 | at | Panhandle State | 40 | CSFL (NAIA) | |||
| Shaw | 6 | at | UNC Pembroke | 16 | CIAA | |||
| 9/26/2015 | Panhandle State | 69 | at | Bacone | 20 | @ CSFL (NAIA) | ||
| Lenoir-Rhyne | 46 | at | Limestone | 22 | SAC | |||
| UNC Pembroke | 17 | at | North Greenville | 40 | ||||
| 10/3/2015 | Kentucky Wesleyan | 35 | at | Central State | 7 | @ SIAC | ||
| Alderson-Broaddus | 27 | at | Fort Valley State | 20 | @ SIAC | |||
| North Greenville | 38 | at | Mars Hill | 14 | @ SAC | |||
| Tuskegee | 17 | at | UNC Pembroke | 29 | SIAC | |||
| Limestone | 12 | at | Wingate | 17 | @ SAC | |||
| 10/10/2015 | North Greenville | 49 | at | Ave Maria | 13 | @ Sun (NAIA) | ||
| Kentucky Wesleyan | 7 | at | Davidson | 14 | OT | @ Pio (1AA) | ||
| Alderson-Broaddus | 18 | at | Duquesne | 53 | @ NE (1AA) | |||
| Catawba | 10 | at | Limestone | 3 | SAC | |||
| Southwestern Texas | 24 | at | Panhandle State | 56 | SCAC (D3) | |||
| 10/15/2015 | Glenville State | 48 | at | Alderson-Broaddus | 30 | MtnE | ||
| 10/17/2015 | Limestone | 28 | at | Brevard | 25 | OT | @ SAC | |
| Panhandle State | 36 | at | McMurry | 35 | OT | @ ASWC (D3) | ||
| UNC Pembroke | 28 | at | North Alabama | 62 | @ GSC | |||
| Tusculum | 24 | at | North Greenville | 35 | SAC | |||
| 10/24/2015 | Georgetown KY | 28 | at | Alderson-Broaddus | 15 | MSC (NAIA) | ||
| UNC Pembroke | 21 | at | Catawba | 39 | @ SAC | |||
| Tusculum | 45 | at | Limestone | 11 | SAC | |||
| Panhandle State | 47 | at | Tarleton State | 84 | @ LSC | |||
| 10/31/2015 | Alfred State | 8 | at | Kentucky Wesleyan | 69 | D3Ind (D3) | ||
| Carson-Newman | 69 | at | Limestone | 28 | SAC | |||
| Texas College | 7 | at | Panhandle State | 62 | CSFL (NAIA) | |||
| West Virginia State | 21 | at | UNC Pembroke | 45 | MtnE | |||
| Alderson-Broaddus | 49 | at | Virginia U-Lynchburg | 20 | @ None (Unk?) | |||
| North Greenville | 27 | at | Wingate | 21 | @ SAC | |||
| 11/7/2015 | North Greenville | 45 | at | Carson-Newman | 48 | @ SAC | ||
| Alderson-Broaddus | 21 | at | Charleston WV | 56 | @ MtnE | |||
| UNC Pembroke | 31 | at | Kentucky Wesleyan | 39 | ||||
| Limestone | 7 | at | Newberry | 47 | @ SAC | |||
| West Texas A&M | 28 | at | Panhandle State | 21 | LSC | |||
| 11/14/2015 | Alderson-Broaddus | 48 | at | Kentucky Wesleyan | 29 | |||
| Panhandle State | 47 | at | Tarleton State | 48 | @ LSC | |||
| Limestone | 14 | at | UNC Pembroke | 31 | ||||
| 11/21/2015 | Kentucky Wesleyan | 27 | at | East Tennessee St | 42 | @ IndFCS (1AA) |