9/3/2015 | Franklin & Marshall | 42 | at | Lebanon Valley | 37 | | | @ MidAC |
| Ursinus | 17 | at | Millersville | 9 | 5OT | | @ PSAC (D2) |
9/4/2015 | Gettysburg | 49 | at | Bridgewater VA | 10 | | | @ ODC |
| Wilkes | 7 | at | Muhlenberg | 35 | | | MidAC |
9/5/2015 | Hobart | 29 | at | Dickinson | 7 | | | LL |
| Grove City | 13 | at | Juniata | 26 | | | TPAC |
| Moravian | 21 | at | King's | 17 | | | @ MidAC |
| Catholic | 34 | at | McDaniel | 33 | | | ODC |
| Johns Hopkins | 52 | at | Randolph-Macon | 17 | | | @ ODC |
| Lycoming | 13 | at | Susquehanna | 28 | | | MidAC |
9/12/2015 | Juniata | 0 | at | Dickinson | 10 | | | |
| Muhlenberg | 15 | at | Franklin & Marshall | 16 | | | |
| Ursinus | 15 | at | Gettysburg | 22 | | | |
| Susquehanna | 7 | at | Johns Hopkins | 59 | | | |
| Moravian | 40 | at | McDaniel | 8 | | | |
9/19/2015 | Gettysburg | 30 | at | Juniata | 25 | | | |
| Johns Hopkins | 45 | at | Moravian | 23 | | | |
| McDaniel | 0 | at | Muhlenberg | 55 | | | |
| Dickinson | 35 | at | Susquehanna | 42 | | | |
| Franklin & Marshall | 17 | at | Ursinus | 13 | | | |
9/26/2015 | Moravian | 55 | at | Dickinson | 38 | | | |
| Juniata | 7 | at | Franklin & Marshall | 24 | | | |
| Susquehanna | 30 | at | Gettysburg | 49 | | | |
| Muhlenberg | 28 | at | Johns Hopkins | 49 | | | |
| McDaniel | 17 | at | Ursinus | 33 | | | |
10/3/2015 | Dickinson | 13 | at | Franklin & Marshall | 7 | | | |
| Johns Hopkins | 41 | at | Juniata | 5 | | | |
| Gettysburg | 45 | at | McDaniel | 17 | | | |
| Ursinus | 3 | at | Moravian | 31 | | | |
| Susquehanna | 24 | at | Muhlenberg | 27 | | | |
10/16/2015 | Dickinson | 7 | at | Johns Hopkins | 34 | | | |
10/17/2015 | Muhlenberg | 41 | at | Gettysburg | 13 | | | |
| Franklin & Marshall | 30 | at | McDaniel | 28 | | | |
| Moravian | 21 | at | Susquehanna | 14 | | | |
| Juniata | 21 | at | Ursinus | 17 | | | |
10/24/2015 | McDaniel | 20 | at | Dickinson | 53 | | | |
| Johns Hopkins | 36 | at | Gettysburg | 7 | | | |
| Muhlenberg | 41 | at | Juniata | 35 | 2OT | | |
| Franklin & Marshall | 19 | at | Moravian | 34 | | | |
| Ursinus | 21 | at | Susquehanna | 48 | | | |
10/31/2015 | Susquehanna | 7 | at | Franklin & Marshall | 16 | | | |
| Ursinus | 13 | at | Johns Hopkins | 49 | | | |
| Juniata | 20 | at | McDaniel | 7 | | | |
| Gettysburg | 32 | at | Moravian | 35 | | | |
| Dickinson | 13 | at | Muhlenberg | 15 | | | |
11/7/2015 | Dickinson | 17 | at | Gettysburg | 20 | | | |
| Franklin & Marshall | 24 | at | Johns Hopkins | 45 | | | |
| Juniata | 10 | at | Moravian | 42 | | | |
| McDaniel | 15 | at | Susquehanna | 44 | | | |
| Muhlenberg | 10 | at | Ursinus | 9 | | | |
11/14/2015 | Ursinus | 28 | at | Dickinson | 20 | | | |
| Gettysburg | 21 | at | Franklin & Marshall | 7 | | | |
| Susquehanna | 24 | at | Juniata | 17 | | | |
| Johns Hopkins | 45 | at | McDaniel | 24 | | | |
| Moravian | 14 | at | Muhlenberg | 28 | | | |
11/21/2015 | Western New England | 20 | at | Johns Hopkins | 52 | | NCAA D3 Championship - First Round | NEF |
11/28/2015 | Wesley | 42 | at | Johns Hopkins | 37 | | NCAA D3 Championship - Second Round | NJAC |