| 8/25/2012 | William Penn (9-3) | 39 | at | Iowa Wesleyan | 14 | MSFA (NAIA) | ||
| 9/1/2012 | Siena Heights (5-5) | 34 | at | Iowa Wesleyan | 36 | MSFA (NAIA) | ||
| 9/8/2012 | Iowa Wesleyan | 14 | at | Taylor (4-6) | 41 | at MSFA | ||
| 9/15/2012 | Lindenwood-Belleville (4-6) | 35 | at | Iowa Wesleyan | 28 | NAIAInd (NAIA) | ||
| 9/22/2012 | Iowa Wesleyan | 13 | at | St Francis IL (6-5) | 52 | at MSFA | ||
| 10/6/2012 | Trinity International (4-7) | 54 | at | Iowa Wesleyan | 24 | MSFA (NAIA) | ||
| 10/13/2012 | Iowa Wesleyan | 14 | vs | Saint Ambrose (9-2) | 23 | Bettendorf IA | vs MSFA | |
| 10/20/2012 | Waldorf (4-7) | 65 | at | Iowa Wesleyan | 66 | MSFA (NAIA) | ||
| 10/27/2012 | Iowa Wesleyan | 28 | at | Olivet Nazarene (3-8) | 39 | at MSFA | ||
| 11/3/2012 | Iowa Wesleyan | 7 | at | Grand View (7-4) | 51 | at MSFA | ||
| 11/10/2012 | Iowa Wesleyan | 41 | at | Concordia MI (0-9) | 7 | at MSFA |
| vs Iowa Wesleyan | vs Other Opponents | Iowa Wesleyan compared to OOs | |
| Record: | 8-3 | 47-59 | |
| Points Scored: | 40.00 | 24.06 | -15.94 |
| Points Allowed: | 25.91 | 27.07 | -1.16 |
| Margin: | 14.09 | -3.01 | -17.10 |
| Total Points: | 65.91 | 51.13 | 14.78 |