| 8/31/2012 | Wisconsin-Whitewater (7-3) | 34 | at | Washington U | 0 | WIAC | ||
| 9/8/2012 | Washington U | 17 | at | Rhodes (6-3) | 20 | OT | at SCAC | |
| 9/15/2012 | Coe (10-1) | 20 | at | Washington U | 14 | IIAC | ||
| 9/22/2012 | Kenyon (6-4) | 23 | at | Washington U | 28 | NCA | ||
| 9/29/2012 | Washington U | 14 | at | DePauw (2-8) | 17 | at NCA | ||
| 10/13/2012 | Wabash (8-2) | 34 | at | Washington U | 14 | NCA | ||
| 10/20/2012 | Washington U | 18 | at | Denison (4-6) | 13 | at NCA | ||
| 10/27/2012 | Carnegie Mellon (6-5,1-2) | 3 | at | Washington U | 15 | |||
| 11/3/2012 | Washington U | 10 | at | Case Western Reserve (6-4,2-1) | 7 | |||
| 11/10/2012 | Washington U | 23 | at | Chicago (4-6,0-3) | 7 |
| vs Washington U | vs Other Opponents | Washington U compared to OOs | |
| Record: | 5-5 | 54-37 | |
| Points Scored: | 17.80 | 24.88 | 7.08 |
| Points Allowed: | 15.30 | 19.52 | -4.22 |
| Margin: | 2.50 | 5.36 | 2.86 |
| Total Points: | 33.10 | 44.40 | -11.30 |