| 9/8/2012 | St Olaf (7-3) | 31 | at | DePauw | 10 | MIA | ||
| 9/15/2012 | DePauw | 14 | at | Wittenberg (10-2,6-1) | 52 | |||
| 9/22/2012 | DePauw | 28 | at | Carnegie Mellon (6-5) | 51 | at UAA | ||
| 9/29/2012 | Washington U (5-5) | 14 | at | DePauw | 17 | UAA | ||
| 10/6/2012 | Ohio Wesleyan (9-1,7-1) | 26 | at | DePauw | 22 | |||
| 10/13/2012 | DePauw | 20 | at | Allegheny (5-5,5-3) | 22 | |||
| 10/20/2012 | Kenyon (6-4,5-2) | 21 | at | DePauw | 19 | |||
| 10/27/2012 | DePauw | 27 | at | Wooster (2-8,1-7) | 16 | |||
| 11/3/2012 | Denison (4-6,4-4) | 39 | at | DePauw | 20 | |||
| 11/10/2012 | DePauw | 0 | at | Wabash (8-2,5-2) | 23 |
| vs DePauw | vs Other Opponents | DePauw compared to OOs | |
| Record: | 8-2 | 54-39 | |
| Points Scored: | 29.50 | 23.98 | -5.52 |
| Points Allowed: | 17.70 | 20.91 | -3.21 |
| Margin: | 11.80 | 3.07 | -8.73 |
| Total Points: | 47.20 | 44.89 | 2.31 |