| 9/1/2012 | Centre | 42 | at | Bethany WV (3-7) | 21 | at TPAC | ||
| 9/8/2012 | Rose-Hulman (4-5) | 21 | at | Centre | 49 | HCA | ||
| 9/15/2012 | Centre | 16 | at | Washington and Lee (8-3) | 34 | at ODC | ||
| 9/22/2012 | Kalamazoo (5-5) | 23 | at | Centre | 35 | MIAA | ||
| 9/29/2012 | Millsaps (7-3,3-1) | 33 | at | Centre | 16 | |||
| 10/6/2012 | Centre | 10 | at | Sewanee (3-7,1-3) | 7 | |||
| 10/20/2012 | Trinity TX (7-3) | 14 | at | Centre | 31 | D3Ind | ||
| 10/27/2012 | Centre | 17 | at | Austin (2-8) | 0 | at D3Ind | ||
| 11/3/2012 | Birmingham-Southern (7-3,3-1) | 45 | at | Centre | 14 | |||
| 11/10/2012 | Centre | 24 | at | Rhodes (6-3,2-2) | 31 |
| vs Centre | vs Other Opponents | Centre compared to OOs | |
| Record: | 4-6 | 48-41 | |
| Points Scored: | 22.90 | 27.84 | 4.94 |
| Points Allowed: | 25.40 | 25.51 | -0.11 |
| Margin: | -2.50 | 2.33 | 4.83 |
| Total Points: | 48.30 | 53.35 | -5.05 |