| 9/1/2012 | Carthage (3-7) | 20 | at | Adrian | 17 | CCIW | ||
| 9/8/2012 | Defiance (2-8) | 13 | at | Adrian | 23 | HCA | ||
| 9/15/2012 | Adrian | 31 | at | Wisconsin Lutheran (7-3) | 23 | at NAC | ||
| 9/29/2012 | Hope (5-5,4-2) | 0 | at | Adrian | 24 | |||
| 10/6/2012 | Adrian | 27 | at | Alma (1-9,1-5) | 3 | |||
| 10/13/2012 | Trine (7-3,5-1) | 3 | at | Adrian | 10 | |||
| 10/20/2012 | Adrian | 28 | at | Olivet (0-10,0-6) | 8 | |||
| 10/27/2012 | Kalamazoo (5-5,2-4) | 7 | at | Adrian | 38 | |||
| 11/3/2012 | Adrian | 20 | at | Albion (6-4,3-3) | 19 | OT | ||
| 11/10/2012 | Adrian | 17 | at | Huntingdon AL (6-3) | 16 | at D3Ind | ||
| 11/17/2012 | Franklin (9-3) | 42 | at | Adrian | 10 | Div 3 Playoffs 1st Round | HCA |
| vs Adrian | vs Other Opponents | Adrian compared to OOs | |
| Record: | 2-9 | 49-51 | |
| Points Scored: | 14.00 | 25.32 | 11.32 |
| Points Allowed: | 22.27 | 25.87 | -3.60 |
| Margin: | -8.27 | -0.55 | 7.72 |
| Total Points: | 36.27 | 51.19 | -14.92 |