| 9/1/2012 | Albion (6-4) | 55 | at | Defiance | 0 | MIAA | ||
| 9/8/2012 | Defiance | 13 | at | Adrian (9-2) | 23 | at MIAA | ||
| 9/15/2012 | Rose-Hulman (4-5,4-3) | 33 | at | Defiance | 20 | |||
| 9/22/2012 | Anderson (0-10,0-8) | 7 | at | Defiance | 30 | |||
| 9/29/2012 | Defiance | 34 | at | Earlham (1-8,1-6) | 10 | |||
| 10/6/2012 | Defiance | 28 | at | Manchester (6-4,6-2) | 34 | |||
| 10/13/2012 | Mt St Joseph (4-6,3-5) | 21 | at | Defiance | 0 | |||
| 10/20/2012 | Defiance | 14 | at | Hanover (6-4,6-2) | 47 | |||
| 10/27/2012 | Franklin (9-3,8-0) | 35 | at | Defiance | 14 | |||
| 11/10/2012 | Defiance | 24 | at | Bluffton (6-4,5-3) | 27 | 2OT |
| vs Defiance | vs Other Opponents | Defiance compared to OOs | |
| Record: | 8-2 | 43-48 | |
| Points Scored: | 29.20 | 23.87 | -5.33 |
| Points Allowed: | 17.70 | 26.52 | -8.82 |
| Margin: | 11.50 | -2.65 | -14.15 |
| Total Points: | 46.90 | 50.39 | -3.49 |