| 9/1/2012 | Southern | 21 | at | New Mexico (4-9) | 66 | at MW | ||
| 9/13/2012 | Mississippi Valley State (5-6,5-4) | 6 | at | Southern | 0 | |||
| 9/22/2012 | Southern | 28 | at | Jackson State (7-5,7-3) | 21 | |||
| 9/29/2012 | Florida A&M (4-7) | 14 | vs | Southern | 21 | Atlanta GA | MEAC | |
| 10/6/2012 | Southern | 17 | at | Alcorn State (4-7,4-5) | 20 | |||
| 10/13/2012 | Texas Southern (2-9,2-7) | 7 | at | Southern | 34 | |||
| 10/20/2012 | Ark Pine Bluff (10-2,9-1) | 50 | at | Southern | 21 | |||
| 10/27/2012 | Prairie View (3-8,3-6) | 49 | vs | Southern | 29 | Shreveport LA | ||
| 11/3/2012 | Southern | 23 | at | Alabama A&M (7-4,6-3) | 24 | OT | ||
| 11/10/2012 | Alabama State (7-4,7-2) | 31 | at | Southern | 30 | |||
| 11/24/2012 | Grambling (1-10,0-9) | 33 | vs | Southern | 38 | New Orleans LA |
| vs Southern | vs Other Opponents | Southern compared to OOs | |
| Record: | 7-4 | 47-67 | |
| Points Scored: | 29.18 | 22.37 | -6.81 |
| Points Allowed: | 23.82 | 27.69 | -3.87 |
| Margin: | 5.36 | -5.32 | -10.68 |
| Total Points: | 53.00 | 50.06 | 2.94 |