| 9/8/2012 | Nicholls State | 3 | at | South Alabama (2-11) | 9 | at SBC | ||
| 9/15/2012 | Nicholls State | 16 | at | Tulsa (11-3) | 66 | at CUSA | ||
| 9/22/2012 | Evangel (7-4) | 17 | at | Nicholls State | 73 | HAAC (NAIA) | ||
| 10/6/2012 | Nicholls State | 14 | at | Central Arkansas (9-3,6-1) | 34 | |||
| 10/13/2012 | Sam Houston (11-4,6-1) | 41 | at | Nicholls State | 0 | |||
| 10/20/2012 | Nicholls State | 10 | at | Stephen F. Austin (5-6,4-3) | 44 | |||
| 10/27/2012 | Nicholls State | 26 | at | Northwestern State (4-7,2-5) | 27 | |||
| 11/3/2012 | McNeese State (7-4,4-3) | 42 | at | Nicholls State | 10 | |||
| 11/10/2012 | Nicholls State | 24 | at | Lamar (4-8,1-6) | 34 | |||
| 11/15/2012 | Southeastern Louisiana (5-6,5-2) | 35 | at | Nicholls State | 16 | |||
| 12/1/2012 | Nicholls State | 3 | at | Oregon State (9-4) | 77 | at P12 |
| vs Nicholls State | vs Other Opponents | Nicholls State compared to OOs | |
| Record: | 10-1 | 64-59 | |
| Points Scored: | 38.73 | 28.83 | -9.90 |
| Points Allowed: | 17.73 | 27.95 | -10.22 |
| Margin: | 21.00 | 0.88 | -20.12 |
| Total Points: | 56.46 | 56.78 | -0.32 |