| 8/30/2012 | McNeese State | 27 | at | Middle Tenn State (8-4) | 21 | at SBC | ||
| 9/8/2012 | McMurry (8-3) | 7 | at | McNeese State | 69 | D2Ind (D2) | ||
| 9/15/2012 | McNeese State | 35 | at | Weber State (2-9) | 21 | at BSky | ||
| 9/22/2012 | McNeese State | 24 | at | Southeastern Louisiana (5-6,5-2) | 25 | |||
| 9/29/2012 | Northwestern State (4-7,2-5) | 22 | at | McNeese State | 30 | |||
| 10/13/2012 | Central Arkansas (9-3,6-1) | 27 | at | McNeese State | 26 | |||
| 10/20/2012 | McNeese State | 10 | at | Sam Houston (11-4,6-1) | 45 | |||
| 10/27/2012 | Stephen F. Austin (5-6,4-3) | 24 | at | McNeese State | 35 | |||
| 11/3/2012 | McNeese State | 42 | at | Nicholls State (1-10,0-7) | 10 | |||
| 11/10/2012 | McNeese State | 24 | at | Texas-San Antonio (8-4) | 31 | at WAC | ||
| 11/17/2012 | Lamar (4-8,1-6) | 0 | at | McNeese State | 35 |
| vs McNeese State | vs Other Opponents | McNeese State compared to OOs | |
| Record: | 4-7 | 61-57 | |
| Points Scored: | 21.18 | 28.48 | 7.30 |
| Points Allowed: | 32.45 | 29.41 | 3.04 |
| Margin: | -11.27 | -0.93 | 10.34 |
| Total Points: | 53.63 | 57.89 | -4.26 |