| 8/30/2012 | West Texas A&M | 34 | at | Colorado State -Pueblo | 44 | @ RMAC | ||
| 9/1/2012 | McMurry | 0 | at | Abilene Christian | 51 | vs D2Ind | ||
| Western State | 14 | at | Angelo State | 42 | vs RMAC | |||
| Texas College | 12 | at | Incarnate Word | 19 | vs CSFL (NAIA) | |||
| Eastern New Mexico | 14 | at | New Mexico Highlands | 42 | @ RMAC | |||
| Southeastern Oklahoma State | 31 | at | Texas A&M-Commerce | 6 | vs GAC | |||
| Central Washington | 7 | at | Texas A&M-Kingsville | 35 | vs GNWAC | |||
| 9/8/2012 | Texas A&M-Kingsville | 16 | at | Abilene Christian | 13 | |||
| Chadron State | 19 | at | Angelo State | 7 | vs RMAC | |||
| Sul Ross State | 35 | at | Eastern New Mexico | 38 | vs ASWC (D3) | |||
| Incarnate Word | 7 | at | Sam Houston | 54 | @ SLC (1AA) | |||
| Midwestern State | 17 | at | Tarleton State | 20 | ||||
| Texas A&M-Commerce | 16 | at | Texas-San Antonio | 27 | @ WAC (1A) | |||
| Western State | 20 | at | West Texas A&M | 57 | vs RMAC | |||
| 9/13/2012 | Texas A&M-Commerce | 14 | vs | Midwestern State | 65 | Arlington TX | ||
| 9/14/2012 | Incarnate Word | 24 | vs | Eastern New Mexico | 34 | Arlington TX | ||
| 9/15/2012 | Valdosta State | 43 | vs | Angelo State | 10 | Arlington TX | vs GSC | |
| Abilene Christian | 34 | vs | Tarleton State | 31 | Arlington TX | |||
| Texas A&M-Kingsville | 10 | vs | West Texas A&M | 40 | Arlington TX | |||
| 9/22/2012 | Abilene Christian | 23 | at | Angelo State | 28 | |||
| West Texas A&M | 24 | at | Incarnate Word | 0 | ||||
| Midwestern State | 45 | at | Texas A&M-Kingsville | 28 | ||||
| Eastern New Mexico | 23 | at | Tarleton State | 35 | ||||
| 9/27/2012 | Abilene Christian | 34 | at | Delta State | 28 | @ GSC | ||
| 9/29/2012 | Angelo State | 49 | at | Eastern New Mexico | 19 | |||
| Incarnate Word | 7 | at | Midwestern State | 34 | ||||
| Texas A&M-Kingsville | 14 | at | Texas A&M-Commerce | 21 | ||||
| Tarleton State | 21 | at | West Texas A&M | 41 | ||||
| 10/4/2012 | Midwestern State | 42 | at | West Alabama | 27 | @ GSC | ||
| 10/6/2012 | Eastern New Mexico | 17 | at | Abilene Christian | 59 | |||
| West Texas A&M | 35 | at | Angelo State | 9 | ||||
| Texas A&M-Commerce | 9 | at | Incarnate Word | 31 | ||||
| North Alabama | 21 | at | Texas A&M-Kingsville | 16 | vs GSC | |||
| Delta State | 38 | at | Tarleton State | 35 | vs GSC | |||
| 10/13/2012 | Angelo State | 28 | at | Midwestern State | 35 | |||
| Tarleton State | 43 | at | Texas A&M-Commerce | 10 | ||||
| Incarnate Word | 17 | at | Texas A&M-Kingsville | 20 | ||||
| Abilene Christian | 0 | at | West Texas A&M | 36 | ||||
| 10/20/2012 | Midwestern State | 35 | at | Abilene Christian | 31 | |||
| Texas A&M-Commerce | 16 | at | Angelo State | 17 | ||||
| West Texas A&M | 44 | at | Eastern New Mexico | 21 | ||||
| McMurry | 28 | at | Incarnate Word | 20 | vs D2Ind | |||
| Texas A&M-Kingsville | 35 | at | Tarleton State | 23 | ||||
| 10/27/2012 | Tarleton State | 45 | at | Incarnate Word | 20 | |||
| Eastern New Mexico | 28 | at | Midwestern State | 51 | ||||
| Abilene Christian | 24 | at | Texas A&M-Commerce | 17 | ||||
| Angelo State | 21 | at | Texas A&M-Kingsville | 34 | ||||
| West Texas A&M | 52 | at | West Georgia | 28 | @ GSC | |||
| 11/1/2012 | Texas A&M-Kingsville | 31 | at | Valdosta State | 38 | @ GSC | ||
| 11/3/2012 | West Alabama | 16 | at | Abilene Christian | 22 | vs GSC | ||
| Incarnate Word | 21 | at | Angelo State | 38 | ||||
| Texas A&M-Commerce | 3 | at | Eastern New Mexico | 7 | ||||
| Tarleton State | 38 | at | North Alabama | 28 | @ GSC | |||
| Midwestern State | 52 | at | West Texas A&M | 48 | ||||
| 11/10/2012 | Abilene Christian | 24 | at | Incarnate Word | 12 | |||
| West Georgia | 17 | at | Midwestern State | 35 | vs GSC | |||
| West Texas A&M | 45 | at | Texas A&M-Commerce | 14 | ||||
| Eastern New Mexico | 13 | at | Texas A&M-Kingsville | 33 | ||||
| Angelo State | 37 | at | Tarleton State | 54 | ||||
| 11/17/2012 | West Texas A&M | 38 | at | Chadron State | 30 | @ RMAC | ||
| Midwestern State | 14 | at | Indianapolis | 31 | @ GLV | |||
| 11/24/2012 | West Texas A&M | 33 | at | Ashland | 28 | D2 Playoffs | @ GLIAC | |
| 11/25/2012 | Texas A&M-Kingsville | 38 | at | Emporia State | 45 | @ MAIAA | ||
| 12/1/2012 | West Texas A&M | 34 | at | Colorado State -Pueblo | 13 | D2 Quarterfinals | @ RMAC | |
| 12/8/2012 | West Texas A&M | 18 | at | Winston-Salem State | 41 | D2 Semifinals | @ CIAA |