| 9/3/2011 | McPherson Bulldogs 10 @ Missouri Valley 47 | |
| 9/10/2011 | MidAmerica Nazarene Pioneers 21 @ Missouri Valley 26 | † |
| 9/17/2011 | Missouri Valley 49 @ Avila Eagles 0 | † |
| 9/24/2011 | Baker Wildcats 7 @ Missouri Valley 38 | † |
| 10/1/2011 | Missouri Valley 48 @ Culver-Stockton Wildcats 14 | † |
| 10/15/2011 | Missouri Valley 19 @ Benedictine KS Ravens 35 | † |
| 10/22/2011 | Graceland Yellow Jackets 0 @ Missouri Valley 78 | † |
| 10/29/2011 | Missouri Valley 13 @ Peru State Bobcats 0 | † |
| 11/5/2011 | Evangel Crusaders 24 @ Missouri Valley 52 | † |
| 11/12/2011 | Missouri Valley 33 @ Central Methodist Eagles 7 | † |
| 11/19/2011 | St Francis IN Fighting Saints 28 @ Missouri Valley 14 ( NAIA FCS Round 1 ) |