| 9/3/2011 | Central Methodist 0 @ MidAmerica Nazarene Pioneers 24 | † |
| 9/10/2011 | Avila Eagles 0 @ Central Methodist 30 | † |
| 9/17/2011 | Central Methodist 7 @ Baker Wildcats 31 | † |
| 9/24/2011 | Culver-Stockton Wildcats 5 @ Central Methodist 42 | † |
| 10/8/2011 | Benedictine KS Ravens 26 @ Central Methodist 3 | † |
| 10/15/2011 | Central Methodist 41 @ Graceland Yellow Jackets 27 | † |
| 10/22/2011 | Peru State Bobcats 10 @ Central Methodist 34 | † |
| 10/29/2011 | Central Methodist 38 @ Evangel Crusaders 7 | † |
| 11/5/2011 | Central Methodist 44 @ SE Missouri State Redhawks 55 | |
| 11/12/2011 | Missouri Valley Vikings 33 @ Central Methodist 7 | † |