| 9/3/2011 | Eastern Kentucky 7 @ Kansas State Wildcats 10 | |
| 9/10/2011 | Missouri State Bears 24 @ Eastern Kentucky 28 | |
| 9/17/2011 | Chattanooga Moccasins 23 @ Eastern Kentucky 14 | |
| 9/24/2011 | Eastern Kentucky 17 @ Austin Peay Governers 23 | † |
| 10/8/2011 | Eastern Kentucky 48 @ Eastern Illinois Panthers 16 | † |
| 10/15/2011 | SE Missouri State Redhawks 17 @ Eastern Kentucky 41 | † |
| 10/22/2011 | Tennessee State Tigers 22 @ Eastern Kentucky 33 | † |
| 10/29/2011 | Eastern Kentucky 34 @ Murray State Racers 33 | † |
| 11/5/2011 | Eastern Kentucky 52 @ Jacksonville State Gamecocks 48 | † |
| 11/12/2011 | Tennessee Tech Golden Eagles 28 @ Eastern Kentucky 21 | † |
| 11/19/2011 | Tennessee-Martin Skyhawks 16 @ Eastern Kentucky 23 | † |
| 11/26/2011 | James Madison Dukes 20 @ Eastern Kentucky 17 ( FCS playoffs ) |