| 9/3/2011 | Northern Iowa Panthers 19 @ Iowa State 20 | |
| 9/10/2011 | Iowa Hawkeyes 41 @ Iowa State 44 3OT | |
| 9/16/2011 | Iowa State 24 @ Connecticut Huskies 20 | |
| 10/1/2011 | Texas Longhorns 37 @ Iowa State 14 | † |
| 10/8/2011 | Iowa State 26 @ Baylor Bears 49 | † |
| 10/15/2011 | Iowa State 17 @ Missouri Tigers 52 | † |
| 10/22/2011 | Texas A&M Aggies 33 @ Iowa State 17 | † |
| 10/29/2011 | Iowa State 41 @ Texas Tech Red Raiders 7 | † |
| 11/5/2011 | Kansas Jayhawks 10 @ Iowa State 13 | † |
| 11/18/2011 | Oklahoma State Cowboys 31 @ Iowa State 37 2OT | † |
| 11/26/2011 | Iowa State 6 @ Oklahoma Sooners 26 | † |
| 12/3/2011 | Iowa State 23 @ Kansas State Wildcats 30 | † |
| 12/30/2011 | Iowa State 13 vs Rutgers Scarlet Knights 27 ( Pinstripe Bowl ) |