| 9/11/2010 | Cortland 24 @ Kean Cougars 12 | † |
| 9/18/2010 | Buffalo State Bengals 7 @ Cortland 35 | † |
| 9/25/2010 | Cortland 45 @ Western Connecticut Colonials 0 | † |
| 10/2/2010 | Cortland 37 @ New Jersey Lions 0 | † |
| 10/9/2010 | Brockport State Golden Eagles 0 @ Cortland 35 | † |
| 10/16/2010 | Cortland 17 @ Rowan Professors 20 | † |
| 10/23/2010 | Cortland 42 @ Morrisville Mustangs 6 | † |
| 10/30/2010 | Montclair State Red Hawks 9 @ Cortland 10 | † |
| 11/6/2010 | William Paterson Pioneers 7 @ Cortland 38 | † |
| 11/13/2010 | Ithaca Bombers 17 @ Cortland 20 | |
| 11/20/2010 | Endicott Power Gulls 35 @ Cortland 49 (D3 Playoffs Round 1) | |
| 11/27/2010 | Alfred Saxons 34 @ Cortland 20 |