| 9/11/2010 | St John Fisher Cardinals 54 @ Buffalo State 26 | |
| 9/18/2010 | Buffalo State 7 @ Cortland Red Dragons 35 | † |
| 9/25/2010 | Kean Cougars 33 @ Buffalo State 29 | † |
| 10/2/2010 | Rowan Professors 24 @ Buffalo State 7 | † |
| 10/9/2010 | Buffalo State 71 @ Western Connecticut Colonials 3 | † |
| 10/16/2010 | Buffalo State 20 @ Montclair State Red Hawks 35 | † |
| 10/23/2010 | New Jersey Lions 48 @ Buffalo State 29 | † |
| 10/30/2010 | Buffalo State 34 @ William Paterson Pioneers 20 | † |
| 11/6/2010 | Morrisville Mustangs 21 @ Buffalo State 45 | † |
| 11/13/2010 | Buffalo State 56 @ Brockport State Golden Eagles 45 | † |