| 8/28/2010 | Virginia Union D2 | vs | Winston-Salem St | ||||||
| 9/4/2010 | Winston-Salem St | @ | NC A&T | MEAC | |||||
| 9/11/2010 | Winston-Salem St | @ | North Carolina Central | ||||||
| 9/18/2010 | Chowan D2 | @ | Winston-Salem St | ||||||
| 9/25/2010 | Winston-Salem St | @ | Fayetteville St D2 | ||||||
| 10/2/2010 | Winston-Salem St | @ | Johnson C Smith D2 | ||||||
| 10/9/2010 | St Augustine's D2 | @ | Winston-Salem St | ||||||
| 10/16/2010 | Livingstone D2 | @ | Winston-Salem St | ||||||
| 10/23/2010 | UNC Pembroke D2 | @ | Winston-Salem St | ||||||
| 10/30/2010 | Winston-Salem St | @ | Shaw D2 |