| 9/3/2009 | William Penn 0 @ South Dakota 52 | |
| 9/12/2009 | South Dakota 7 @ Northern Iowa 66 | |
| 9/19/2009 | Drake 21 @ South Dakota 51 | |
| 9/26/2009 | SE Louisiana 13 @ South Dakota 44 | |
| 10/3/2009 | South Dakota 12 @ North Dakota 27 | † |
| 10/10/2009 | UC Davis 24 @ South Dakota 23 1OT | † |
| 10/17/2009 | South Dakota 24 @ Montana St 31 1OT | |
| 10/31/2009 | South Dakota 17 @ N Colorado 21 | |
| 11/7/2009 | S Utah 21 @ South Dakota 45 | † |
| 11/14/2009 | South Dakota 50 @ Cal Poly 48 | † |