| 9/5/2009 | Grand View 0 @ Drake 22 | |
| 9/12/2009 | Drake 34 @ Marist 6 | † |
| 9/19/2009 | Drake 21 @ South Dakota 51 | |
| 10/3/2009 | Valparaiso 14 @ Drake 34 | † |
| 10/10/2009 | Missouri S&T 0 @ Drake 19 | |
| 10/17/2009 | Drake 21 @ San Diego 14 | † |
| 10/24/2009 | Drake 21 @ Davidson 16 | † |
| 10/31/2009 | Jacksonville 38 @ Drake 45 | † |
| 11/7/2009 | Campbell 6 @ Drake 49 | † |
| 11/14/2009 | Dayton 23 @ Drake 6 | † |
| 11/21/2009 | Drake 17 @ Butler 20 | † |