| 8/29/2009 | New Mexico Highlands 0 @ Midwestern St 41 | |
| 9/5/2009 | Midwestern St 34 @ SE Oklahoma St 6 | † |
| 9/12/2009 | Northeastern St OK 3 @ Midwestern St 52 | † |
| 9/19/2009 | Midwestern St 49 @ Incarnate Word 7 | |
| 9/26/2009 | Midwestern St 17 @ Angelo St 20 | † |
| 10/3/2009 | West Texas A&M 19 @ Midwestern St 31 | † |
| 10/10/2009 | Midwestern St 38 @ Tarleton St 31 | † |
| 10/17/2009 | TAMU-Kingsville 7 @ Midwestern St 38 | † |
| 10/24/2009 | Central Oklahoma 16 @ Midwestern St 43 | † |
| 10/31/2009 | Midwestern St 50 @ Eastern New Mexico 17 | † |
| 11/7/2009 | Abilene Christian 13 @ Midwestern St 15 | † |
| 11/14/2009 | Abilene Christian 24 @ Midwestern St 21 (D2) | † |