| 8/29/2009 | Central Oklahoma 13 @ Pittsburg St 42 | |
| 9/5/2009 | Central Oklahoma 24 @ West Texas A&M 17 | † |
| 9/12/2009 | Central Oklahoma 17 @ TAMU-Kingsville 46 | † |
| 9/19/2009 | Tarleton St 35 @ Central Oklahoma 17 | † |
| 9/26/2009 | Central Oklahoma 23 @ TAMU-Commerce 27 | † |
| 10/3/2009 | Southwest Baptist 31 @ Central Oklahoma 23 | |
| 10/10/2009 | Central Oklahoma 24 @ SE Oklahoma St 41 | † |
| 10/17/2009 | SW Oklahoma St 23 @ Central Oklahoma 41 | † |
| 10/24/2009 | Central Oklahoma 16 @ Midwestern St 43 | † |
| 10/31/2009 | Central Oklahoma 42 @ East Central OK 25 | † |
| 11/7/2009 | Northeastern St OK 38 @ Central Oklahoma 47 | † |