| 9/5/2009 | Nicholls St 0 @ Air Force 72 | |
| 9/12/2009 | Duquesne 7 @ Nicholls St 14 | |
| 9/19/2009 | Nicholls St 13 @ Louisiana Tech 48 | |
| 9/26/2009 | Jacksonville St 60 @ Nicholls St 10 | |
| 10/10/2009 | Nicholls St 21 @ Sam Houston 44 | † |
| 10/17/2009 | Texas St 34 @ Nicholls St 28 | † |
| 10/24/2009 | Nicholls St 13 @ Central Arkansas 42 | † |
| 10/31/2009 | McNeese St 38 @ Nicholls St 17 | † |
| 11/7/2009 | Nicholls St 27 @ SF Austin 31 | † |
| 11/14/2009 | Northwestern St 21 @ Nicholls St 28 | † |
| 11/19/2009 | Nicholls St 45 @ SE Louisiana 30 | † |